Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

230
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
230
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

8.3K
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
8.3K
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

57
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
57
Computed Tomography01:10

Computed Tomography

4.7K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.7K
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

335
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
335
Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

184
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
184

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proton therapy range uncertainty reduction using vendor-agnostic tissue characterization on a virtual photon-counting CT head scan.

Medical physics·2026
Same author

Correction: The effect of OsteoStrong compared to dynamic multicomponent exercise on bone strength in older women: the BONEMORE non-inferiority randomized controlled trial.

Archives of osteoporosis·2026
Same author

Optimizing energy settings in CdTe, CZT, and Si photon-counting CT for material separation and detection.

Physics in medicine and biology·2026
Same author

Precise Lung Density Quantification with a Physics-based CT Harmonizer.

Radiology. Cardiothoracic imaging·2026
Same author

Demographic distribution matching between real-world and virtual phantom population.

Medical physics·2026
Same author

The effect of OsteoStrong compared to dynamic multicomponent exercise on bone strength in older women: the BONEMORE non-inferiority randomized controlled trial.

Archives of osteoporosis·2026
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Related Experiment Video

Updated: Aug 15, 2025

Author Spotlight: Standardization and Best Practices for Advancing Lung Imaging Using 129Xe MRI
09:08

Author Spotlight: Standardization and Best Practices for Advancing Lung Imaging Using 129Xe MRI

Published on: November 21, 2023

947

Phase-contrast virtual chest radiography.

Ilian Häggmark1, Kian Shaker1, Sven Nyrén2,3

  • 1Department of Applied Physics, KTH Royal Institute of Technology, 114 19, Stockholm, Sweden.

Proceedings of the National Academy of Sciences of the United States of America
|December 29, 2022
PubMed
Summary
This summary is machine-generated.

Phase-contrast chest radiography shows promise for visualizing small airways, aiding in early detection of lung diseases like asthma. However, it offers minimal improvement for detecting pulmonary nodules compared to conventional X-rays.

Keywords:
X- ray imagingchest radiographyphase contrastvirtual clinical trial

More Related Videos

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
05:32

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph

Published on: February 21, 2025

371
Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
05:56

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Published on: August 9, 2024

1.7K

Related Experiment Videos

Last Updated: Aug 15, 2025

Author Spotlight: Standardization and Best Practices for Advancing Lung Imaging Using 129Xe MRI
09:08

Author Spotlight: Standardization and Best Practices for Advancing Lung Imaging Using 129Xe MRI

Published on: November 21, 2023

947
Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
05:32

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph

Published on: February 21, 2025

371
Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
05:56

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Published on: August 9, 2024

1.7K

Area of Science:

  • Medical Imaging
  • Radiology
  • Computational Imaging

Background:

  • Phase-contrast X-ray imaging offers enhanced visualization of airways in animal models.
  • Clinical translation of phase-contrast X-ray technology is limited by current technological constraints.
  • The clinical impact of phase-contrast chest radiography remains an open question.

Purpose of the Study:

  • To evaluate the potential clinical impact of phase-contrast chest radiography using an in silico framework.
  • To assess the effectiveness of phase-contrast edge enhancement for pulmonary nodule detection and small airway visualization.
  • To identify requirements for the clinical implementation of phase-contrast chest radiography.

Main Methods:

  • Utilized a realistic in silico framework with preprocessed virtual patients.
  • Generated in silico chest radiographs using Fresnel-diffraction simulations of X-ray wave propagation.
  • Conducted a reader study with clinical radiologists to evaluate image interpretation.

Main Results:

  • Phase-contrast edge enhancement showed a negligible impact on detecting solitary pulmonary nodules (6-20 mm).
  • Edge enhancement effectively visualized small airways (< 2 mm) invisible in conventional radiography.
  • Phase-contrast imaging could enable observation of small-airway obstruction, relevant for asthma and COPD.

Conclusions:

  • Phase-contrast chest radiography holds potential for diagnosing small-airway diseases currently undetectable by conventional methods.
  • Further experimental development is motivated to translate phase-contrast imaging into clinical practice.
  • Quantitative specifications for X-ray sources, detectors, and distances are crucial for clinical implementation.