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How ginseng regulates autophagy: Insights from multistep process
Hangui Ren1, Rongchen Dai1, Yinchen Chen2
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 29, 2022
Summary
Ginseng compounds modulate autophagy, a cellular process implicated in various diseases. This review explores ginseng
Area of Science:
- Cellular Biology
- Pharmacology
- Pathogenesis
Background:
- Autophagy is a key cellular process involved in human disease pathogenesis.
- Current FDA-approved autophagy inhibitors are limited to chloroquine and hydroxychloroquine.
- Ginseng extracts and ginsenosides show therapeutic potential by modulating autophagy.
Purpose of the Study:
- To systematically review the relationship between ginseng and autophagy.
- To identify key regulators in ginseng-autophagy pathways for drug development.
- To provide insights into novel therapeutic strategies utilizing ginseng and autophagy.
Main Methods:
- Comprehensive literature review of studies on ginseng, autophagy, and disease treatment.
- Analysis of molecular mechanisms by which ginseng components regulate autophagy.
- Examination of the interplay between autophagy and apoptosis in disease contexts.
Main Results:
- Ginseng components regulate key steps in autophagy: initiation, autophagosome biogenesis, and degradation.
- Ginseng exhibits dual effects on autophagy (induction and inhibition) depending on the disease context.
- Ginseng-regulated autophagy is implicated in treating cancers, neurological, and cardiovascular diseases, inflammation, and neurotoxicity.
Conclusions:
- Ginseng's modulation of autophagy offers a promising therapeutic avenue for various diseases.
- Understanding ginseng-autophagy interactions, including dual effects and cross-talk with apoptosis, is crucial for therapeutic development.
- Further research into ginseng-autophagy pathways can lead to novel drug discovery.
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