Related Experiment Video
Updated: Aug 15, 2025
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
Published on: February 24, 2021
The impact of adding platelet-rich plasma during fat graft myringoplasty for managing medium-sized tympanic membrane
Mahmoud F Mandour1, Mohamed N Elsheikh1, Mohamed Amer1
1Otorhinolaryngology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Purpose:
This study aimed to evaluate the effect of adding platelet-rich plasma (PRP) during FGM to close medium-sized TM perforations.
Methods:
This prospective randomized case-control study was conducted from February 2017 to March 2022. We included 320 patients with a medium-sized TM perforation with inactive mucosal otitis media. Transcanal FGM managed all patients under general or local anesthesia according to the patient preference. According to PRP, patients were divided into two groups: the first with PRP (170 patients) and the other without PRP (150 patients). We evaluated the closure rate of both groups one month, six months, and one year after the surgery. Also, we assessed the audiological performance before and one year after the operation for the patients with a successful closure.
Results:
The closure rate was 87.6 % in the first group and 72.7 % in the second group, with a statistically significant difference between both groups as the P-value, was 0.001. Successful closure of the ABG to <10 dB occurred in 95.3 % of group A and 90.8 % of group B without a statistically significant difference between both groups (P-value = 0.163).
Conclusions:
This prospective comparative study on a relatively large number of patients revealed that FGM effectively closed medium-sized TM perforations. It also significantly improved postoperative audiological performance in both groups. Adding PRP during the FGM enhanced the closure success and the healing process without recorded complications. We recommend using the PRP in the routine FGM for closing medium-sized TM perforations.
Insights
Adding platelet-rich plasma (PRP) to fiber membrane grafting (FGM) significantly improves closure rates for medium-sized tympanic membrane perforations. This technique enhances healing and audiological outcomes without complications, making it a recommended surgical addition.
Area of Science:
- Otolaryngology
- Regenerative Medicine
- Surgical Innovation
Background:
- Medium-sized tympanic membrane (TM) perforations can impair hearing and predispose to infections.
- Fiber membrane grafting (FGM) is an established technique for TM perforation closure.
- Optimizing FGM outcomes, particularly closure rates and healing, remains an area of clinical interest.
Purpose of the Study:
- To evaluate the efficacy of adding platelet-rich plasma (PRP) to FGM for closing medium-sized TM perforations.
- To compare closure rates and audiological outcomes between FGM with and without PRP.
- To assess the safety and potential benefits of PRP in this surgical context.
Main Methods:
- A prospective randomized case-control study involving 320 patients with medium-sized TM perforations.
- Patients underwent transcanal FGM, with 170 receiving PRP and 150 not receiving PRP.
- Closure rates were assessed at one month, six months, and one year post-surgery; audiological performance was evaluated before and after surgery.
Main Results:
- The FGM with PRP group showed a significantly higher closure rate (87.6%) compared to the FGM without PRP group (72.7%) (P=0.001).
- Successful closure of the air-bone gap (ABG) to <10 dB was achieved in 95.3% of the PRP group and 90.8% of the non-PRP group, a non-significant difference.
- Both groups demonstrated significant improvement in postoperative audiological performance.
Conclusions:
- FGM is effective for closing medium-sized TM perforations and improving hearing.
- The addition of PRP to FGM significantly enhances the closure success rate and healing process.
- PRP is a safe adjunct to FGM for TM perforations, with no recorded complications, and is recommended for routine use.
More Related Videos
14:49Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
Published on: September 29, 2018
09:07Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration
Published on: January 26, 2024