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Injection of baclofen into the ventromedial hypothalamus stimulates gastric motility in the rat
K L Wood1, J I Addae, P L Andrews
1Department of Physiology, St. George's Hospital Medical School, London, U.K.
Neuropharmacology
|August 1, 1987
Abstract:
Injection of 2 micrograms (+/-)-baclofen into the ventromedial hypothalamus (VMH) of urethane-anaesthetized rats resulted in an increase in gastric tone and amplitude of contractions. This effect was curtailed by administration of atropine methyl nitrate (20 mg/kg i.p.) or bilateral cervical vagotomy. These results provide evidence for a hypothalamic modulation of gastric motility by the vagus. Baclofen, possibly acting on receptors insensitive to gamma-aminobutyric acid (GABA), may be mimicking a vagal activation system, located within the ventro-medial hypothalamus.