Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

4.4K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
4.4K
Inflammation01:38

Inflammation

54.4K
Overview
54.4K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

210
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
210
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

12.0K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
12.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI-enabled clinical decision support in breast cancer care: a blinded multicenter benchmarking study comparing medically specialized with a general-purpose system.

Journal of medical systems·2026
Same author

Early Feasibility Studies in Europe: A Multisite Qualitative Study of Operational Challenges and Site Selection Determinants at 6 University Hospitals.

Clinical therapeutics·2026
Same author

Machine learning improves online self-referral for inflammatory rheumatic diseases: a registry-based validation study.

Rheumatology international·2026
Same author

Comparative analysis of large language models and traditional diagnostic decision support systems for rare rheumatic disease identification.

EULAR rheumatology open·2026
Same author

Patient self-assessment and virtual visit-based treatment decisions in rheumatoid arthritis: results from the multicentre Telemedicine in Rheumatoid Arthritis trial.

EULAR rheumatology open·2026
Same author

Physicians' attitudes and perceived diagnostic confidence in point-of-care ultrasound in gynecology and obstetrics (GO-POCUS): a prospective single-center implementation study with structured training.

BMC medical education·2026
Same journal

Reassessing the Proposed Creatine-PrP Axis in Endometriosis: Methodological and Mechanistic Considerations.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

IL-7R-Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Systematic Phosphorus-Driven Structural and Field Engineering of n-a-Si:H for Flexible n-a-Si:H/Te Near-Infrared Photodetectors.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Chemically Gradient Ordered Nanodomains Enable Large Tensile Ductility in Gigapascal Lightweight Refractory High-Entropy Alloys.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Single-Molecule Characterization of Bacterial Factor-Dependent Transcription Activation by Rob.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
See all related articles

Related Experiment Video

Updated: Aug 15, 2025

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.8K

Inflammation-Controlled Anti-Inflammatory Hydrogels.

Tina Helmecke1, Dominik Hahn1, Nadine Matzke1

  • 1Leibniz Institute of Polymer Research Dresden, Institute of Biofunctional Polymer Materials, Hohe Strasse 6, 01069, Dresden, Germany.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|December 29, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces an adaptive polymer hydrogel that releases anti-inflammatory drugs in response to blood inflammation. This smart biomaterial offers controlled drug delivery for medical devices, enhancing safety without compromising immune function.

Keywords:
drug deliveryelastasefeedback controlhydrogelinflammation

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.0K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

11.4K

Related Experiment Videos

Last Updated: Aug 15, 2025

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.8K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.0K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

11.4K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Immunology

Background:

  • Autoregulation is common in tissues, but few adaptive biomaterials exist.
  • Existing biomaterials lack controlled, feedback-responsive drug delivery.

Purpose of the Study:

  • To develop a novel polymer hydrogel platform for feedback-controlled release of anti-inflammatory drugs.
  • To demonstrate adaptive drug delivery triggered by inflammatory responses in human blood.

Main Methods:

  • Conjugating anti-inflammatory peptide drugs to a hydrogel via an elastase-cleavable linker.
  • Utilizing activated granulocytes and their released elastase to trigger drug release.
  • Demonstrating drug efficacy on inflammatory pathways and tuning release profiles.

Main Results:

  • The hydrogel successfully released anti-inflammatory drugs in response to activated granulocytes.
  • Adjusting hydrogel functionalization allowed tuning of drug release to micromolar doses.
  • The released drugs effectively modulated target inflammatory pathways.

Conclusions:

  • This feedback-controlled hydrogel system enables adaptive drug delivery for medical devices.
  • Covalently conjugated drug release offers safety by avoiding general immunosurveillance suppression.
  • The platform is suitable for delivering potent anti-inflammatory agents precisely when needed.