Related Experiment Video
Updated: Aug 15, 2025
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
Introduction and Clinical Validation of an Updated Biomechanically Corrected Intraocular Pressure bIOP (v2)
Ashkan Eliasy1, Bernardo T Lopes1,2, Junjie Wang3
1School of Engineering, University of Liverpool, Liverpool, UK.
Purpose:
To improve the stability of the Corvis ST biomechanically-corrected intraocular pressure measurements (bIOP) after refractive surgery and its independence of corneal biomechanics.
Methods:
A parametric study was carried out using numerical models simulating the behavior of the eye globe under the effects of IOP and Corvis ST external air pressure and used to develop a new algorithm for bIOP; bIOP(v2). It was tested on 528 healthy participants to evaluate correlations with CCT and age. Its ability to compensate for the geometrical changes was tested in 60 LASIK and 80 SMILE patients with six months follow up. The uncorrected Corvis ST IOP (CVS-IOP) and the two versions of biomechanically corrected IOP; bIOP(v1) and bIOP(v2), were compared.
Results:
In the healthy dataset, bIOP(v2) had weak and non-significant correlation with both CCT (R = -0.048, p = .266) and age (R = 0.085, p = .052). For bIOP(v1), the correlation was non-significant with CCT (R = -0.064, p = .139) but significant with age (R = -0.124, p < .05). In both LASIK and SMILE groups, the median change in bIOP(v2) following surgery was below 1 mmHg at follow-up stages and the interquartile range was smaller than both bIOP(v1) and CVS-IOP.
Conclusion:
The bIOP(v2) algorithm performs better than bIOP(v1) and CVS-IOP in terms of correlation with CCT and age. The bIOP(v2) also demonstrated the smallest variation after LASIK and SMILE refractive surgeries indicating improved ability to compensate for geometrical changes.
