Recent progress in ferroptosis: inducers and inhibitors

Area of Science:

• Biochemistry
• Cell Biology
• Pathology

Background:

• Ferroptosis is an iron-dependent programmed cell death involving lipid peroxidation.
• It is closely linked to the pathophysiology of numerous diseases, driving research into its mechanisms and targets.
• Key targets like glutathione peroxidase 4 (GPX4) and System Xc- have been identified, with associated inducers and inhibitors developed.

Purpose of the Study:

• To review critical regulatory targets within the ferroptosis metabolic pathway.
• To categorize and present commonly used and novel ferroptosis inducers and inhibitors.
• To discuss the medical applications of these ferroptosis modulators.

Main Methods:

• Literature review of ferroptosis mechanisms and targets.
• Compilation and classification of known ferroptosis inducers and inhibitors.
• Analysis of current and potential therapeutic applications.

Main Results:

• Identification of key molecular targets regulating ferroptosis.
• Categorization of various ferroptosis inducers and inhibitors based on their development status and mechanisms.
• Discussion of the therapeutic relevance of targeting ferroptosis in disease.

Conclusions:

• Ferroptosis research is vital for understanding and treating diseases.
• Effective selection and application of inducers and inhibitors are critical for therapeutic success.
• Future research should focus on novel targets and refined therapeutic strategies for ferroptosis.