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Testosterone is associated with abdominal body composition derived from computed tomography: a large cross sectional
Seungbong Han1, Young-Jee Jeon2, Tae Young Lee3
1Department of Biostatistics, Korea University College of Medicine, Seoul, Korea.
Scientific Reports
|December 29, 2022
Summary
Serum testosterone levels are linked to abdominal muscle mass and subcutaneous fat in men. Higher testosterone correlates with more abdominal muscle and less subcutaneous fat, independent of metabolic syndrome factors.
Area of Science:
- Endocrinology
- Radiology
- Body Composition Analysis
Background:
- Serum testosterone plays a role in male physiology.
- Abdominal obesity is a key indicator of metabolic health.
- Abdominopelvic computed tomography (APCT) provides detailed body composition data.
Purpose of the Study:
- To investigate the association between serum testosterone levels and abdominal body composition.
- To analyze this relationship using APCT measurements.
- To adjust for metabolic syndrome components in the analysis.
Main Methods:
- Cross-sectional study of 1453 adult males (22-84 years).
- Abdominal body composition assessed via APCT.
- Linear regression analysis used to determine associations with testosterone, adjusting for clinical factors.
Main Results:
- Testosterone negatively associated with subcutaneous fat area index (p<0.001).
- Testosterone positively associated with total abdominal muscle area index (p<0.001), normal attenuation muscle area index (p<0.001), and lower attenuation muscle area index (p=0.002).
- Associations remained significant after adjusting for age, metabolic syndrome components, and other clinical factors.
Conclusions:
- Serum testosterone is significantly associated with abdominal muscle mass and subcutaneous fat.
- Testosterone is negatively correlated with subcutaneous fat but not visceral fat.
- Testosterone is positively correlated with abdominal muscle, irrespective of muscle fat infiltration.
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