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Interactions of melatonin with various signaling pathways: implications for cancer therapy

Ainaz Mihanfar1, Bahman Yousefi2, Bita Azizzadeh3

  • 1Solid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.

Cancer Cell International
|December 29, 2022
PubMed

Insights

Melatonin, a neuro-hormone regulating circadian rhythms, shows potential in cancer treatment. This review explores how melatonin impacts cancer signaling pathways for therapeutic benefit.

Area of Science:

  • Neuroendocrinology
  • Oncology
  • Molecular Biology

Background:

  • Melatonin is an evolutionarily conserved neuro-hormone.
  • Initially recognized for antioxidant and circadian rhythm regulation, it interacts with cellular receptors.
  • Melatonin influences key signaling pathways involved in cellular processes.

Purpose of the Study:

  • To review the role of melatonin in regulating signaling pathways crucial for cancer progression.
  • To present evidence on the potential of targeting malignancies with melatonin.

Main Methods:

  • Literature review of studies on melatonin and cancer signaling.
  • Analysis of melatonin's interaction with cytoplasmic and intra-nuclear receptors.
  • Examination of melatonin's regulatory effects on key mediators in cancer pathways.

Main Results:

  • Melatonin regulates multiple signaling pathways implicated in cancer.
  • Evidence suggests melatonin's beneficence in targeting various malignancies.
  • Melatonin's ability to modulate signaling pathways offers clinical significance in oncology.

Conclusions:

  • Melatonin demonstrates a significant role in modulating cancer progression through various signaling pathways.
  • Targeting these pathways with melatonin presents a promising therapeutic strategy for malignancies.
  • Further research into melatonin's oncostatic potential is warranted.
Keywords:
Anti-cancerMelatoninSignaling pathways

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