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[An overview of risk factors for stroke]

E A Koltsova1, E A Petrova1, Y V Borshch1

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|December 30, 2022
PubMed

Insights

Understanding stroke requires recognizing its diverse causes and risk factors. Identifying and managing modifiable genetic and environmental factors is key to reducing stroke

Area of Science:

  • Neurology
  • Genetics
  • Public Health

Context:

  • Stroke is a complex neurological condition with varied causes, including ischemic and hemorrhagic types.
  • Effective treatment and prevention strategies necessitate understanding the specific pathogenesis of stroke.
  • Genetic factors play a role in stroke risk and may be more amenable to modification than previously assumed.

Purpose:

  • To explore the heterogeneity of stroke, differentiating risk factors, treatments, and prevention strategies based on pathogenesis.
  • To highlight the importance of understanding genetic mechanisms underlying stroke risk.
  • To emphasize the need for identifying and managing modifiable risk factors for stroke prevention.

Summary:

  • Stroke is a heterogeneous syndrome where risk factors, treatments, and prevention depend on specific pathogenesis.
  • While ischemic and hemorrhagic stroke share some risk factors, significant differences exist, alongside the concept of stroke triggers.
  • Understanding genetic mechanisms of stroke risk is crucial for developing new therapeutic and preventive strategies, as genetic factors may be modifiable.

Impact:

  • Provides a framework for personalized stroke risk assessment and management.
  • Underscores the potential for novel therapeutic and preventive interventions targeting genetic predispositions.
  • Aims to reduce the global burden of stroke through timely identification and management of modifiable risk factors.

Keywords:
hemorrhagic strokeischemic strokerisk factorsstrokestroke preventionstroke triggers

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