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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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[Ethiopathogenetic features and course of ischemic stroke associated with COVID-19]

L B Novikova1, R F Latypova1

  • 1Bashkir State Medical University, Ufa, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|December 30, 2022
PubMed

Insights

COVID-19 patients experienced more severe ischemic strokes, often with unknown causes and elevated inflammatory markers. Cardiovascular risk factors were less common, suggesting unique disease pathways requiring further investigation.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiology

Context:

  • The association between COVID-19 and ischemic stroke is an emerging area of clinical concern.
  • Understanding the unique characteristics of stroke in COVID-19 patients is crucial for effective management.

Purpose:

  • To investigate the etiopathogenetic factors and clinical course of ischemic stroke in patients with COVID-19.
  • To compare stroke characteristics and risk factors between COVID-19 positive and negative ischemic stroke patients.

Summary:

  • A retrospective study of 173 COVID-19 positive and 86 COVID-19 negative ischemic stroke patients revealed significant differences.
  • COVID-19 patients had less frequent cardiovascular risk factors but experienced more severe strokes, with a higher prevalence of unknown subtypes (TOAST classification).
  • Elevated renal-hepatic markers and C-reactive protein indicated systemic inflammation in the COVID-19 group.

Impact:

  • Findings highlight that COVID-19 influences stroke severity and etiology, independent of traditional cardiovascular risk factors.
  • The increased severity and distinct etiological profile in COVID-19 associated strokes necessitate tailored diagnostic and therapeutic strategies.
  • Further research is warranted to elucidate the negative prognostic impact of cardiovascular disease in COVID-19 patients and optimize treatment.
Abstract

Keywords:
COVID-19cryptogenic subtypeischemic stroke

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