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Formulation of pH-Responsive Methacrylate-Based Polyelectrolyte-Stabilized Nanoparticles for Applications in Drug
Bumjun Kim1, Dawei Zhang1, Madeleine S Armstrong1
1Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey08544, United States.
ACS Applied Nano Materials
|December 30, 2022
Summary
Methacrylate-based anionic copolymers stabilize nanoparticles for drug delivery. Their molecular properties control nanoparticle size, offering a tunable platform for nanomedicine development.
Area of Science:
- Polymer Science
- Nanotechnology
- Materials Science
Background:
- Methacrylate-based anionic copolymers (MACs) are established enteric coatings for oral drug delivery.
- Limited molecular understanding exists regarding MACs as nanoparticle stabilizers.
Purpose of the Study:
- Investigate MACs for creating therapeutic nanoparticles.
- Elucidate the role of MAC molecular properties in nanoparticle assembly via flash nanoprecipitation.
Main Methods:
- Flash nanoprecipitation was employed to assemble nanoparticles.
- Nanoparticle size was tuned by varying degree of neutralization, ionic strength, mass concentration, and core-to-MAC ratio.
Main Results:
- Nanoparticle size (59–454 nm) is controllable via MAC molecular properties and assembly conditions.
- Nanoparticle size correlates with the ratio of hydrophilic surface domains to hydrophobic core domains.
- Findings apply to both polymer-based cores and small-molecule drugs.
Conclusions:
- MAC molecular properties significantly influence nanoparticle assembly and size.
- Established principles guide the development of polyelectrolyte copolymer-stabilized nanomedicines.
- Demonstrated pH-responsive behavior of MAC-stabilized nanoparticles.
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