Related Experiment Videos
Fibrinogen-induced vitreous membranes
A M Mansour1, J Chess, P Henkind
1Department of Ophthalmology, Montefiore Medical Center/Albert Einstein College of Medicine, New York, N.Y.
Ophthalmic Research
|January 1, 1987
Summary
Fibrinogen injections in rabbit eyes caused vitreous membrane formation, which later resolved. This study highlights fibrin
Area of Science:
- Ophthalmology
- Cell Biology
- Biochemistry
Background:
- Vitreous membrane formation is a key feature in proliferative vitreoretinopathy.
- The role of fibrin in vitreous disease pathogenesis requires further elucidation.
Purpose of the Study:
- To investigate the effects of fibrinogen injection into the vitreous cavity of rabbits.
- To assess the potential of fibrinogen as a model for vitreous membrane formation and resolution.
Main Methods:
- Fibrinogen was injected into the vitreous cavity of 29 rabbits.
- Ophthalmoscopy and histopathological studies were used for evaluation.
- Histochemical stains were employed to detect fibrinogen.
Main Results:
- Vitreous membrane formation was significantly more frequent in the fibrinogen group compared to controls.
- These membranes showed a decrease in size and eventual liquefaction within 15 days.
- Fibrinogen was detected in half of the observed vitreous membranes.
Conclusions:
- Fibrinogen injection can induce transient vitreous membrane formation, likely via fibrin polymerization.
- The vitreous's fibrinolytic system facilitates the resolution of these membranes.
- While not a perfect model for chronic bands, fibrinogen's role in vitreoproliferative diseases is supported, and its induced membranes show reversibility similar to some proliferative vitreoretinopathies.