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Individual-level behavioral interventions to support optimal development of children with sickle cell disease: A

Catherine R Hoyt1,2,3, Sadie Hurwitz1, Taniya E Varughese1

  • 1Program in Occupational Therapy, Washington University School of Medicine, St. Louis, Missouri, USA.

Pediatric Blood & Cancer
|December 30, 2022
PubMed

Insights

Behavioral interventions for children with sickle cell disease (SCD) show promise, particularly for disease knowledge, self-management, and pain management. More research is needed for very young children and developmental impacts.

Area of Science:

  • Pediatric Hematology
  • Behavioral Science
  • Public Health

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder requiring comprehensive management strategies.
  • Individual-level behavioral interventions are crucial for improving health outcomes in pediatric SCD patients.
  • A systematic review is needed to synthesize existing evidence on these interventions.

Approach:

  • This review followed PRISMA guidelines for systematic reviews.
  • Twenty-seven studies investigating behavioral interventions for children (0-18 years) with SCD were included.
  • Interventions were categorized into six types: disease knowledge, self-management, pain management, school functioning, cognitive health, and mental health.

Key Points:

  • Six intervention types were identified, with disease knowledge and self-management having the most studies (n=7 each).
  • Pain management and school functioning interventions were also represented (n=4 each).
  • Most interventions focused on older children (5+ years), with limited research for infants and toddlers (0-3 years).

Conclusions:

  • Behavioral interventions focusing on disease knowledge, self-management, and pain management appear beneficial for children with SCD.
  • There is a significant gap in research regarding interventions for very young children (0-3 years) with SCD.
  • Further investigation is required to understand the impact of SCD on child development and to develop targeted interventions for all age groups.

Keywords:
child developmentdevelopmental delayinterventionrehabilitationsickle cell disease

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