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Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Retinal Vascular Geometry in Hypertension: cSLO-Based Method.

Hongyu Kong1, Wei Lou2, Jiaojie Li3

  • 1Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

Ophthalmology and Therapy
|December 30, 2022
PubMed
Summary
This summary is machine-generated.

Confocal scanning laser ophthalmoscopy (cSLO) can measure retinal vascular geometry. Hypertension is negatively correlated with arterial/arteriolar branch angle, arteriolar vessel diameter, and fractal dimension.

Keywords:
OCTRetinal vascular geometrycSLO

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Cardiovascular Research

Background:

  • Retinal vascular geometry assessment is crucial for understanding cardiovascular health.
  • Confocal scanning laser ophthalmoscopy (cSLO) offers a non-invasive method for retinal imaging.
  • Existing methods for quantifying retinal vascular geometry have limitations.

Purpose of the Study:

  • To introduce and validate cSLO-based methods for measuring retinal vascular geometry.
  • To analyze vessel branch angle (BA), diameter, tortuosity, and fractal dimension (Df).
  • To investigate the relationship between hypertension and these retinal vascular metrics.

Main Methods:

  • Utilized infrared cSLO images from 119 participants (72 normotensive, 47 hypertensive).
  • Extracted images from scans around the optic disc using a cSLO + OCT instrument.
  • Analyzed images using ImageJ software for geometric parameter quantification.

Main Results:

  • cSLO-based geometric analyses demonstrated high repeatability (ICC > 0.80).
  • Normotensive subjects showed significantly higher arterial/arteriolar BA, arteriolar diameter, and total Df compared to hypertensive subjects (P < 0.05).
  • These parameters remained negatively correlated with hypertension after adjusting for age and gender.

Conclusions:

  • Developed cSLO-based methods for retinal vascular geometry assessment are repeatable and reproducible.
  • Arterial/arteriolar BA, arteriolar vessel diameter, and total Df are significantly associated with hypertension.
  • Arteriolar tortuosity and venous parameters did not show significant differences between hypertensive and normotensive groups.