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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Bullous Pemphigoid Masquerading as Erythrodermic Psoriasis.

N L P De-Kaa1, S A Adefemi2, R T Akuhwa3

  • 1Department of Family Medicine, Federal Medical Centre, Makurdi, Benue State, Nigeria.

West African Journal of Medicine
|December 30, 2022
PubMed
Summary

Bullous pemphigoid, a rare autoimmune skin disease, can mimic Erythrodermic Psoriasis in adolescents. This case highlights the importance of considering Bullous Pemphigoid in adolescent autoimmune skin scaling disorders.

Keywords:
Auspitz signBullaeErythrodermic PsoriasisPemphigoid

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Area of Science:

  • Dermatology
  • Autoimmune Diseases
  • Pediatric Dermatology

Background:

  • Bullous pemphigoid (BP) is a rare autoimmune blistering skin disease typically affecting the elderly.
  • Erythrodermic psoriasis (EP) is a severe form of psoriasis characterized by widespread erythema and scaling.
  • Both conditions are autoimmune skin disorders with potential overlapping symptoms.

Observation:

  • This report details a unique case of Bullous Pemphigoid presenting atypically in an adolescent.
  • Initial presentation mimicked Erythrodermic Psoriasis with massive scaling and intense itching.
  • Vesicles, blisters, and bullae became apparent during treatment, leading to a revised diagnosis.

Findings:

  • Histological examination confirmed Bullous Pemphigoid, despite the initial presentation resembling Erythrodermic Psoriasis.
  • Bullous pemphigoid can exhibit polymorphic presentations, including features typically associated with other dermatoses.
  • The case underscores the diagnostic challenge posed by atypical presentations of Bullous Pemphigoid.

Implications:

  • This case highlights the need for a broad differential diagnosis in adolescents presenting with severe scaling skin conditions.
  • Early recognition and appropriate diagnostic workup are crucial for managing Bullous Pemphigoid effectively in younger populations.
  • Understanding the varied presentations of Bullous Pemphigoid can improve diagnostic accuracy and patient outcomes.