Related Experiment Video
Updated: Jun 27, 2026
Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
Published on: July 16, 2018
Samarium-Based Turn-Off Fluorescence Sensor for Sensitive and Selective Detection of Quinolinic Acid in Human Urine
Bao-Ding Zhang1, Bing Liu1, Yu-Xing Yin1
1College of Chemistry and Chemical Engineering, Shaanxi Key Laboratory of Chemical Additives for Industry, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi Province, P. R. China.
Abstract:
Quinolinic acid (QA) is an index for some diseases, whose detection is of importance. This work presents a samarium metal-organic framework (Sm-MOF) containing 5-sulfoisophthalate ligand (SIP3-). The fluorescence of Sm-MOF integrates the emission at 339 nm from the SIP3- ligand and four characteristic 4G5/2 → 4H (j = 5/2, 7/2, 9/2, and 11/2) transitions at 559, 596, 642, and 701 nm from Sm(III). Sm-MOF as a turn-off fluorescence sensor to QA exhibits high sensitivity, selectivity, and durability. The fluorescence quenching response to QA shows a linear relationship of I0/I = 0.00496·CQA + 1.12474 in the QA concentration of 0-500 μM and a limit of detection calculated as 4.11 μM. Sm-MOF shows the structural and fluorescent stabilities in five quenching-recovery cycles. The recoveries of close to 100% in human urine and serum indicate high reliability. The paper-based Sm-MOF sensor displays a rough QA quantitative analysis by recognizing red values in the on-site QA detection.
