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Related Concept Videos

X-ray Imaging01:24

X-ray Imaging

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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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Roadmap for precision preclinical x-ray radiation studies.

Frank Verhaegen1,2, Karl T Butterworth3, Anthony J Chalmers4

  • 1MAASTRO Clinic, Radiotherapy Division, GROW-School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Physics in Medicine and Biology
|December 30, 2022
PubMed
Summary

This roadmap details precision preclinical x-ray radiation studies in animal models, focusing on cancer and normal tissue responses. It highlights technological advancements and future directions for radiation research and clinical translation.

Keywords:
cancer modelsdosimetryimagingirradiationprecisionpreclinicaltranslation

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Area of Science:

  • Preclinical radiation oncology
  • Animal models in research
  • Radiation biology

Background:

  • Precision preclinical studies are crucial for understanding radiation effects.
  • Animal models are essential for cancer and normal tissue response research.
  • Technological progress is rapidly advancing radiation research capabilities.

Purpose of the Study:

  • To provide a roadmap for precision preclinical x-ray radiation studies.
  • To discuss technological evolution and future developments in the field.
  • To explore clinical translation and reverse translation of radiation research findings.

Main Methods:

  • Review of technological advancements in imaging, irradiation, dosimetry, and monitoring.
  • Discussion of various animal models for radiation studies.
  • Analysis of clinical and reverse translation strategies.

Main Results:

  • Recent technological evolution has significantly empowered preclinical radiation studies.
  • Numerous future developments are anticipated in imaging, irradiation, and monitoring.
  • The importance of integrating preclinical findings with clinical applications is emphasized.

Conclusions:

  • Precision preclinical radiation studies in animal models are rapidly evolving.
  • Technological innovation is key to advancing our understanding of radiation effects.
  • Effective clinical translation and reverse translation are vital for therapeutic progress.