Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development and Validation of a Pathomics Model for Prognosis Prediction in Neoadjuvant Therapy-Treated Breast Cancer: A Retrospective, Multicenter Study.

MedComm·2026

Same author

Associations between vitamin D levels, nutritional status, and inflammation in sepsis ‒ A cross-sectional study.

Nutricion hospitalaria·2026

Same author

β2-Microglobulin Induces Mitochondrial Dysfunction Accompanied by Bronchial Epithelial Cell Senescence.

International journal of chronic obstructive pulmonary disease·2026

Same author

Mechanisms Associated with PINK1 Variants in Parkinson's Disease.

F1000Research·2026

Same author

Clinical large language model centered on electronic medical records.

NPJ digital medicine·2026

Same author

Causal effects among hypertension, osteoporosis, and metabolites: A Mendelian randomization study.

Journal of the Chinese Medical Association : JCMA·2026

Search research articles

Related Experiment Video

Updated: Aug 15, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

A sequentially responsive cascade nanoplatform for increasing chemo-chemodynamic therapy.

Xu Cheng¹, Lu Wang¹, Liwen Liu¹

¹School of Life Sciences, Anqing Normal University, Anqing 246052, PR China.

Colloids and Surfaces. B, Biointerfaces

|December 30, 2022

Summary

This summary is machine-generated.

This study developed a novel hybrid polymer nanosystem using Poly(lactide-co-glycolide) (PLGA) to improve cancer drug delivery. The system enhances tumor targeting, drug release, and therapeutic efficacy against drug-resistant lung cancer.

Keywords:

Active-targeting DePEGylation Fenton reaction GSH depletion Gas-triggered drugs release

More Related Videos

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

Related Experiment Videos

Last Updated: Aug 15, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

Area of Science:

Biomaterials Science
Nanotechnology
Cancer Therapy

Background:

Poly(lactide-co-glycolide) (PLGA) is a promising drug carrier for cancer therapy.
Limitations of PLGA include slow degradation and lack of targeting, hindering clinical effectiveness.
Novel nanocarrier systems are needed to overcome these limitations.

Purpose of the Study:

To fabricate a hybrid nanosystem addressing PLGA limitations for enhanced cancer treatment.
To improve blood stability, tumor targeting, and drug release kinetics.
To achieve synergistic therapeutic effects through combined chemotherapy and chemodynamic therapy (CDT).

Main Methods:

Fabrication of a hybrid nanosystem (3P@He/Pt-NPs) with acid-sensitive (mPOE-PLGA) and targeting (PBA-PLGA) polymers.
Encapsulation of therapeutic agents: hemin and cisplatin.
Evaluation of PEGylation for stability, dePEGylation and active-targeting for cellular uptake, and hemin-catalyzed oxygen generation for drug release.

Main Results:

The hybrid nanosystem demonstrated enhanced blood stability and circulation time due to PEGylation.
Efficient cellular uptake was achieved via dePEGylation and PBA-mediated active-targeting in tumor regions.
Hemin catalyzed oxygen bubble generation, increasing drug release rate and enhancing cell-killing effects.
Cisplatin amplified CDT by H2O2 regeneration, while hemin reduced GSH levels, boosting cisplatin efficacy.
The system achieved an 83.2% inhibition rate against drug-resistant lung cancer cells.

Conclusions:

The developed hybrid polymer nanosystem effectively overcomes the limitations of traditional PLGA nanocarriers.
This system enables cascading enhanced tumor treatment through combined chemotherapy and CDT.
The nanocarrier shows significant potential for treating drug-resistant tumors.