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Acylations in cardiovascular biology and diseases, what's beyond acetylation
Xin Sun1, Yang Zhang2, Xiao-Feng Chen3
1Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, State Key Laboratory of Biotherapy, West China Second University Hospital, West China Hospital, Sichuan University, Chengdu, 610041, China; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Insights
This review explores novel non-acetyl lysine acylations in cardiovascular biology. Understanding these epigenetic modifications offers new therapeutic targets for cardiovascular diseases.
Area of Science:
- Cardiovascular Biology
- Epigenetics
- Metabolism
Background:
- Metabolism influences cardiovascular biology via epigenetic modifications.
- Histone acetylation is crucial for cardiovascular health and disease, with therapeutic potential.
- Novel non-acetyl lysine acylations are emerging as significant regulators.
Purpose of the Study:
- To review current understanding of non-acetyl lysine acylations in cardiovascular biology.
- To discuss the physiological and pathological roles of these modifications.
- To explore translational perspectives for treating cardiovascular diseases.
Main Methods:
- Literature review of experimental and preclinical studies.
- Analysis of recent research on non-acetyl lysine acylations in cardiovascular contexts.
- Synthesis of evidence on epigenetic mechanisms in cardiovascular biology.
Main Results:
- Non-acetyl lysine acylations play significant physiological and pathological roles.
- These modifications offer a broader insight into epigenetic regulation of the cardiovascular system.
- Targeting acylations presents potential therapeutic strategies for cardiovascular diseases.
Conclusions:
- Non-acetyl lysine acylations are critical in cardiovascular biology.
- Further research is needed to fully elucidate their roles and therapeutic potential.
- Targeting these epigenetic marks could lead to novel treatments for cardiovascular diseases.
Abstract:
Metabolism regulates cardiovascular biology through multiple mechanisms, including epigenetic modifications. Over the past two decades, experimental and preclinical studies have highlighted the critical roles of histone modifications in cardiovascular development, homeostasis, and diseases. The widely studied histone acetylation is critical in cardiovascular biology and diseases, and inhibitors of histone deacetylases show therapeutic values. In addition to lysine acetylation, a series of novel non-acetyl lysine acylations have recently been recognized. These non-acetyl lysine acylations have been demonstrated to have physiological and pathological functions, and recent studies have analyzed the roles of these non-acetyl lysine acylations in cardiovascular biology. Herein, we review the current advances in the understanding of non-acetyl lysine acylations in cardiovascular biology and discuss open questions and translational perspectives. These new pieces of evidence provide a more extensive insight into the epigenetic mechanisms underlying cardiovascular biology and help assess the feasibility of targeting acylations to treat cardiovascular diseases.
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