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Updated: Aug 15, 2025

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
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Published on: February 21, 2019

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Cordycepin and kinase inhibition in cancer

Md Asaduzzaman Khan1, Mousumi Tania2

  • 1The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan, China; Nature Study Society of Bangladesh, Dhaka, Bangladesh.

Drug Discovery Today
|December 30, 2022
PubMed

Insights

Cordycepin from Cordyceps mushrooms shows anticancer potential by targeting key signaling molecules called kinases. This natural compound may disrupt cancer cell growth by interfering with kinase pathways crucial for tumor development.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Cordycepin, a nucleoside from Cordyceps mushrooms, exhibits various health benefits, notably anticancer activities.
  • Cancer development and progression are often linked to abnormal kinase expression and signaling.
  • Kinases play critical roles in cellular processes, making them significant targets in cancer therapy.

Purpose of the Study:

  • To review the potential anticancer mechanisms of cordycepin focusing on kinase targeting.
  • To explore how cordycepin interacts with specific kinase pathways implicated in cancer.

Main Methods:

  • Literature review of studies investigating cordycepin's effects on cancer cells.
  • Analysis of research on kinase signaling pathways involved in cancer.
  • Examination of molecular mechanisms through which cordycepin may inhibit kinases.

Main Results:

  • Cordycepin has been shown to target multiple kinases, including JNK, MAPK, AMPK, PI3K/Akt, ERK, mTOR, GSK-3β, and FAK.
  • Disruption of these kinase pathways by cordycepin may contribute to its anticancer effects.
  • Kinase inhibition is a recognized strategy in cancer treatment, highlighting cordycepin's therapeutic potential.

Conclusions:

  • Targeting kinases represents a significant molecular mechanism underlying the anticancer properties of cordycepin.
  • Cordycepin's ability to modulate kinase activity offers a promising avenue for novel cancer therapies.
  • Further research into cordycepin as a kinase inhibitor could lead to new cancer treatment strategies.
Keywords:
cancercancer treatmentcordycepinkinase pathways

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