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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Physicians' attitudes, knowledge, and practices regarding antibiotic prescriptions.

Fatma Al Rahbi1, Issa Al Salmi2, Faryal Khamis3

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Physicians

Keywords:
Antimicrobial resistance (AMR)AttitudesKnowledgePhysiciansPractices

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Area of Science:

  • Medical Science
  • Infectious Diseases
  • Public Health

Background:

  • Antimicrobial resistance (AMR) is a significant global health threat.
  • Inappropriate antimicrobial use, incorrect dosing, and extended duration contribute to AMR.
  • Judicious antimicrobial prescribing is crucial to combat drug-resistant pathogens.

Purpose of the Study:

  • To evaluate physician knowledge, attitudes, and practices regarding rational antibiotic prescribing.
  • To identify knowledge gaps for targeted interventions.
  • To promote judicious antimicrobial use and reduce AMR in Oman.

Main Methods:

  • Cross-sectional study conducted at the Royal Hospital, Oman (January-March 2020).
  • Assessed physicians' knowledge and attitudes towards antibiotic prescribing using Likert scales.
  • Evaluated awareness and perception of personal performance in patient care and rational antibiotic use.

Main Results:

  • Inadequate hand washing (51.6%) and widespread antibiotic use (49%) were identified as key AMR contributors.
  • Prescribing broad-spectrum antibiotics (47.3%) and inappropriate duration (46.2%) were also significant factors.
  • Lack of local guidelines and poor access to resistance data were noted barriers.

Conclusions:

  • AMR poses a substantial threat to health systems and economies worldwide.
  • Misuse and overuse of antimicrobials are primary drivers of drug-resistant pathogens.
  • Interventions, including Antimicrobial Stewardship Programs, are essential to reduce AMR.