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Papillary Thyroid Carcinoma With Squamous Dedifferentiation: A Potential Diagnostic Pitfall.
1Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, MO, U.S.A.
Anticancer Research
|December 30, 2022
Summary
This case report details a rare instance of squamous cell carcinoma (SCC) of the thyroid developing from papillary thyroid carcinoma (PTC). Awareness of this dedifferentiation is crucial for accurate diagnosis and treatment of thyroid cancer.
Area of Science:
- Oncology
- Pathology
- Endocrinology
Background:
- Squamous cell carcinoma (SCC) of the thyroid is an uncommon thyroid neoplasm.
- Dedifferentiation from papillary thyroid carcinoma (PTC) is a potential pathway for SCC development.
Observation:
- A 76-year-old male presented with dysphagia and weight loss.
- Imaging revealed a hypopharyngeal mass and bilateral thyroid nodules.
- Surgical resection showed moderately differentiated SCC in the pyriform sinus and conventional PTC in the peritracheal region.
Findings:
- PAX8 immunoreactivity confirmed the thyroid origin of the SCC.
- Metastatic SCC and PTC were found in a paratracheal lymph node.
- Histopathological evaluation revealed dedifferentiation from PTC to SCC.
Implications:
- This rare case highlights a diagnostic challenge in thyroid cancer.
- Increased awareness of SCC arising from PTC dedifferentiation is needed.
- Clinic-histopathological correlation is essential for optimal diagnosis and treatment of this rare thyroid malignancy.
