Related Experiment Video

Updated: Aug 15, 2025

Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients
07:25

Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients

Published on: July 16, 2020

3.2K

Association between histo-blood group antigens and Pseudomonas aeruginosa-associated diarrheal diseases

Chih-Hsien Chuang1, Rajendra Prasad Janapatla2, Yi-Hsin Wang2

  • 1Department of Pediatrics, St. Paul's Hospital, Taoyuan, Taiwan; Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan; School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|December 30, 2022
PubMed

Insights

Children with blood group A and the Lewis phenotype Le(a+b+) are more susceptible to Pseudomonas aeruginosa-associated diarrheal diseases. Infants exhibit a higher gut colonization rate of this bacterium compared to older children.

Area of Science:

  • Microbiology
  • Immunology
  • Genetics

Background:

  • Pseudomonas aeruginosa is an opportunistic pathogen, rarely causing enteric infections.
  • The role of human histo-blood group antigens (HBGAs) in P. aeruginosa enteric infections remains uninvestigated.

Purpose of the Study:

  • To investigate the association between HBGAs and P. aeruginosa-associated diarrheal diseases in children.
  • To determine P. aeruginosa gut colonization rates in different pediatric age groups.

Main Methods:

  • Collected stool samples from children to assess P. aeruginosa gut colonization.
  • Analyzed saliva samples from patients and healthy children for ABO blood group, FUT2 genotype, and Lewis phenotype (ELISA).

Main Results:

  • Infants showed a higher P. aeruginosa colonization rate (6.9%) than children aged 1-2 years (2.3%).
  • Blood group A (31.2% vs 17.6%) and Lewis phenotype Le(a+b+) (30.9% vs 16.2%) were significantly more prevalent in children with P. aeruginosa diarrhea.
  • No association was found between HBGA status and disease severity.

Conclusions:

  • Infants have a higher gut colonization rate of P. aeruginosa.
  • Children with blood group A and the Le(a+b+) phenotype are predisposed to P. aeruginosa-associated diarrheal diseases.
Abstract

Keywords:
ChildrenColonizationDiarrheaHisto-blood group antigensPseudomonas aeruginosa

More Related Videos

Methods for Detecting Cytotoxic Amyloids Following Infection of Pulmonary Endothelial Cells by Pseudomonas aeruginosa07:27

Methods for Detecting Cytotoxic Amyloids Following Infection of Pulmonary Endothelial Cells by Pseudomonas aeruginosa

Published on: July 12, 2018

5.6K
Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

9.0K

Related Concept Videos

The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
1.9K
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
18.0K
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.3K
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
254
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.9K