Related Experiment Video

Updated: Aug 15, 2025

Ultrasonic Assessment of Myocardial Microstructure
10:53

Ultrasonic Assessment of Myocardial Microstructure

Published on: January 14, 2014

5.5K

Efficacy of Biomarkers in Identifying Abnormal Echocardiogram in Multisystem Inflammatory Syndrome in Children

Rajan Arora1, Usha Sethuraman1, David M Merolla2

  • 1Division of Pediatric Emergency Medicine, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA.

Clinical Pediatrics
|December 31, 2022
PubMed

Insights

Cardiac biomarkers like troponin and BNP can help identify heart issues in children with multisystem inflammatory syndrome (MIS-C). Elevated levels may indicate the need for an urgent echocardiogram to detect cardiac abnormalities.

Area of Science:

  • Pediatric Cardiology
  • Pediatric Critical Care
  • Infectious Diseases

Background:

  • Cardiac involvement is a significant concern in children diagnosed with multisystem inflammatory syndrome (MIS-C).
  • Early detection of cardiac abnormalities is crucial for managing morbidity and mortality associated with MIS-C.

Purpose of the Study:

  • To evaluate the effectiveness of cardiac biomarkers, specifically high-sensitivity troponin I (hs-TnI) and B-type natriuretic peptide (BNP), in identifying abnormal echocardiograms in pediatric patients with MIS-C.

Main Methods:

  • A retrospective chart review was conducted on 83 children diagnosed with MIS-C.
  • Sensitivity and specificity of hs-TnI and BNP were calculated for detecting echocardiographic abnormalities.

Main Results:

  • 39.8% of MIS-C patients exhibited abnormal echocardiograms.
  • BNP demonstrated higher sensitivity, while hs-TnI >50 ng/L showed greater specificity.
  • Children with hs-TnI >50 ng/L had a significantly higher likelihood of echocardiographic abnormalities (RR 4.9).

Conclusions:

  • Elevated cardiac biomarkers, particularly hs-TnI (>50 ng/L) and BNP, are indicative of cardiac involvement in MIS-C.
  • Children with abnormal BNP and/or troponin levels (especially >3x ULN) warrant urgent echocardiography in emergency settings.

Keywords:
BNPMIS-Cechocardiogramtroponin

More Related Videos

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.0K
A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

16.8K

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
43
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
18
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
229
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
20
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
323
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
401