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Updated: Aug 15, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Asymmetrical Platinum and Rhodium Dinuclear Complex Strongly Bound to Filled d Complexes by Unbridged Pt-Metal
Kazuhiro Uemura1, Yuya Ikeda1, Atsushi Takamori1
1Department of Chemistry and Biomolecular Science Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu, 501-1193, Japan.
Abstract:
Heterometallic extended metal atom chains (EMACs) aligned with three types of metal were rationally synthesized by forming unbridged metal-metal bonds based on the interactions between highest occupied and lowest unoccupied molecular orbitals at the d orbital. These chains form pentanuclear structures aligned as Rh-Pt-M-Pt-Rh with relatively large formation constants of 5.0×1013 M-2 for M=Pt and 6.3×1011 M-2 for M=Pd, while retaining their backbones in solution. In the case of M=Cu, the original Cu(+2) atoms were reduced to Cu(+1) during the synthetic process. Cu(+1) has an unprecedented trigonal bipyramidal coordination geometry. The reported synthesis based on asymmetrical dinuclear complexes provides a guideline for the synthesis of hetero-EMACs to allow several analogs through judicious combinations realized by tuning the number of metal nuclei and metal species.
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