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Related Experiment Video

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Conformable neural interface based on off-stoichiometry thiol-ene-epoxy thermosets.

Eleonora Borda1, Danashi Imani Medagoda1, Marta Jole Ildelfonsa Airaghi Leccardi1

  • 1Medtronic Chair in Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne, Switzerland.

Biomaterials
|December 31, 2022
PubMed
Summary

Off-stoichiometry thiol-ene-epoxy (OSTE+) thermosets offer a novel material for neural implants due to their conformability and biocompatibility. This study demonstrates their use in a micro-electrocorticography array for neural recording and stimulation in mice.

Keywords:
BiocompatibilityBrain-machine interfaceConformabilityMicro-electrocorticographyNeural interfaceOSTE+

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Area of Science:

  • Biomaterials Science
  • Neuroscience Engineering
  • Polymer Science

Background:

  • Off-stoichiometry thiol-ene-epoxy (OSTE+) thermosets exhibit desirable properties like low permeability, minimal molecular absorption, and low Young's modulus.
  • These characteristics make OSTE+ suitable for microfluidic chip prototyping and show potential for neural implants due to mechanical properties and cleanroom compatibility.

Purpose of the Study:

  • To investigate the suitability of OSTE+ as a material for implantable neural interfaces.
  • To develop and evaluate a conformable micro-electrocorticography (ECoG) array using OSTE+ for neural recording and stimulation.

Main Methods:

  • Fabrication of a multilayer micro-ECoG array with 16 platinum electrodes coated with platinum black using OSTE+.
  • Evaluation of the array's mechanical conformability to curved surfaces.
  • Assessment of device stability, biocompatibility, and performance in acute and chronic implantation studies in mice.

Main Results:

  • The OSTE+ micro-ECoG array demonstrated conformability to the mouse cortex, enabling multimodal recording and stimulation of neural tissue.
  • The material exhibited low permeability and strong layer adhesion, contributing to device stability.
  • Implantation studies showed no cytotoxicity and only a modest foreign body response after chronic implantation.

Conclusions:

  • OSTE+ is a promising material for developing conformable and stable implantable neural interfaces.
  • The fabricated OSTE+ micro-ECoG array successfully recorded and stimulated neural tissue in vivo.
  • The material's biocompatibility and mechanical properties support its application in neural implants.