The simplified iodine-specific food frequency questionnaire can evaluate iodine intake in Chinese adults

We hypothesized that an effective iodine-specific food frequency questionnaire (I-FFQ) simplification method could expand the application of the I-FFQ in evaluating long-term iodine intake. An adult I-FFQ was developed and was simplified by deleting food items with iodine contribution rates ≤0.1%, combining food items with similar species and iodine contribution rates, and calculating the iodine content of combined food by a weighted calculation method. A 3-day (3-d) diet diary tested the validity of the I-FFQ. We evaluated the relationship between iodine intake estimated using the I-FFQ and the urinary iodine to creatinine ratio, thyroid volume (Tvol), and thyroid function. The Kappa value was 0.62 for the original I-FFQ and the 3-d diet diary (P < .001), 0.78 for the short-version I-FFQ and the 3-d diet diary (P < .001), and 0.76 for the original I-FFQ and the short-version I-FFQ (P < .001). The mean difference before and after simplification was 27.1 µg/d. The Tvol was different between the I-FFQ groups and showed an upward trend (P for trend = .01). Tvol was higher in the 284 347 µg/d (β = 0.72; 95% CI, 0.16-1.28; P = .01) groups after simplification. The I-FFQ is an effective method for evaluating iodine nutritional status in adults. After streamlining, the food items were reduced from 58 to 15, which shortened the investigation time while retaining evaluation efficiency; it is also easier to get the cooperation of the subjects and improve the availability of I-FFQ.