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Related Experiment Video

Updated: Aug 15, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

CircNRIP1: An emerging star in multiple cancers.

¹College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.

Pathology, Research and Practice

|December 31, 2022

Summary

This summary is machine-generated.

Circular RNAs (circRNAs) are stable molecules implicated in disease. Circular RNA nuclear receptor interacting protein 1 (circNRIP1) is linked to various cancers and regulates key signaling pathways, showing diagnostic and therapeutic potential.

Keywords:

Biomarker Cancer CircNRIP1 Circular RNA Tumor progression

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Last Updated: Aug 15, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Area of Science:

Molecular Biology
Genetics
Oncology

Background:

Circular RNAs (circRNAs) are novel non-coding RNAs with a unique closed-loop structure.
These molecules are highly stable and prevalent in the eukaryotic cytoplasm.
Emerging evidence highlights the significant role of circRNAs in diverse disease pathologies.

Purpose of the Study:

To review the biological functions of circNRIP1 in carcinogenesis.
To elucidate the target molecular mechanisms of circNRIP1.
To explore the clinical potential of circNRIP1 in cancer diagnosis and treatment.

Main Methods:

Literature review of studies on circNRIP1 and cancer.
Analysis of circNRIP1's role in regulating signaling pathways (ERK1/2, PI3K/AKT, AKT/mTOR).
Synthesis of current research on circNRIP1's involvement in various cancer types.

Main Results:

Circular RNA nuclear receptor interacting protein 1 (circNRIP1) is associated with cervical carcinoma, colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, nasopharyngeal carcinoma, non-small cell lung cancer, osteosarcoma, ovarian cancer, and papillary thyroid carcinoma.
CircNRIP1 influences the activity of critical signaling pathways including ERK1/2, PI3K/AKT, and AKT/mTOR.
These regulatory functions suggest a role for circNRIP1 in cancer development.

Conclusions:

CircNRIP1 is a significant factor in the pathogenesis of multiple cancers.
Understanding circNRIP1's molecular mechanisms offers insights into cancer biology.
CircNRIP1 holds promise as a biomarker for cancer diagnosis and a therapeutic target.