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Updated: Aug 15, 2025
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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
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Is there a role for herpes simplex virus type 1 in multiple sclerosis?
Luisa F Duarte1, Sebastian Gatica1, Almendra Castillo1
1Millennium Institute on Immunology and Immunotherapy, Departamento de Ciencias Biológicas, Facultad de Ciencias de La Vida, Universidad Andres Bello, Santiago, Chile.
Microbes and Infection
|December 31, 2022
Summary
Herpes simplex virus type 1 (HSV-1) is a neurotropic virus found in the brain. This review explores the potential links between HSV-1 infections and the development and severity of multiple sclerosis (MS).
Area of Science:
- Neurovirology
- Immunology
- Neurology
Background:
- Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
- Viral infections are increasingly implicated in the pathogenesis of MS.
- Herpes simplex virus type 1 (HSV-1) is a common neurotropic virus with a proposed role in MS.
Conclusions:
- HSV-1 is a significant candidate in the multifactorial etiology of MS.
- Understanding the HSV-1-MS connection may offer new therapeutic targets.
- Continued investigation into viral triggers for autoimmune neurological diseases is crucial.
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