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Updated: Aug 15, 2025
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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
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Early-Onset Sepsis in Newborns
Courtney Briggs-Steinberg1,2, Philip Roth1,2
1Division of Neonatology, Department of Pediatrics, Staten Island University Hospital, Northwell Health, Staten Island, NY.
Pediatrics in Review
|December 31, 2022
Summary
Early-onset sepsis in newborns poses significant risks. Identifying risk factors and common pathogens like group B Streptococcus is crucial for timely intervention and reducing infant mortality.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
Background:
- Early-onset sepsis (EOS) is a major cause of neonatal morbidity and mortality.
- Risk factors include maternal group B Streptococcus colonization, intra-amniotic infection, and prolonged membrane rupture.
Purpose of the Study:
- To summarize the key aspects of early-onset sepsis in newborns.
- To highlight common causative organisms and clinical presentations.
Main Methods:
- Review of established medical literature on neonatal sepsis.
- Analysis of risk factors, pathogens, and clinical signs.
Main Results:
- Common pathogens causing EOS are group B Streptococcus, Escherichia coli, and viridans streptococci.
- Respiratory distress is the most frequent presenting symptom in neonates with sepsis.
Conclusions:
- Clinical presentation of sepsis can mimic non-infectious respiratory issues.
- Balancing empirical antibiotic treatment versus observation is critical for infants with risk factors or respiratory distress.
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