Association between basal septal hypertrophy and left ventricular geometry in a community population

Related Experiment Video

Updated: Aug 15, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.1K

Lan Gao1,2, Wei Ma3,4, Min Li1

  • 1Division of Cardiology, Department of Cardiovascular Disease, Peking University First Hospital, Dahongluochang Street, Xicheng District, Beijing, 100034, China.

BMC Cardiovascular Disorders
|December 31, 2022
PubMed

Insights

Basal septal hypertrophy (BSH) is linked to changes in left ventricular (LV) geometry, specifically an increased relative wall thickness (RWT). This finding highlights BSH as an independent predictor of altered LV geometry in a community population.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiovascular Imaging

Background:

  • Left ventricular (LV) geometry is crucial in cardiovascular disease.
  • Limited research exists on basal septal hypertrophy (BSH) and its association with LV geometry.
  • This study investigates the relationship between BSH and LV geometry within a Beijing community cohort.

Purpose of the Study:

  • To examine the association between basal septal hypertrophy (BSH) and left ventricular (LV) geometry.
  • To determine the prevalence of BSH in a Chinese community population.
  • To identify predictors of BSH in relation to LV mass index (LVMI) and relative wall thickness (RWT).

Main Methods:

  • Analysis of clinical and echocardiographic data from 1032 participants.
  • Definition of BSH: basal interventricular septal thickness ≥ 14 mm and basal septal thickness/mid-septal thickness ≥ 1.3.
  • Multivariable logistic regression to assess the relationship between BSH, LVMI, and RWT.

Main Results:

  • BSH prevalence was 7.4% in the study population.
  • The BSH group exhibited greater septal and posterior wall thickness, and higher RWT, with lower LVMI and LV end-diastolic dimension compared to the non-BSH group.
  • BSH was independently associated with a relative wall thickness (RWT) > 0.42 (OR 3.99, p < 0.01).

Conclusions:

  • Basal septal hypertrophy (BSH) is independently associated with increased relative wall thickness (RWT) > 0.42.
  • BSH is a significant indicator of altered left ventricular geometry.
  • The findings contribute to understanding the clinical implications of BSH in cardiovascular health.
Abstract

Keywords:
Basal septal hypertrophyEchocardiographyLeft ventricular geometry

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

2.9K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

3.8K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
30
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
25
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
29
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
28
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
23
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
41