A novel promising neuroprotective agent: Ganoderma lucidum polysaccharide

Area of Science:

• Neuroscience
• Pharmacology
• Natural Products

Background:

• Nervous system diseases (NSDs) present complex challenges in treatment due to varied symptoms, pathophysiology, and therapeutic responses.
• Ganoderma lucidum (GL), a traditional medicine, offers health benefits.
• Ganoderma lucidum polysaccharides (GLP) are key active compounds in GL with diverse pharmacological effects.

Purpose of the Study:

• To review recent research on Ganoderma lucidum polysaccharides (GLP) for nervous system diseases (NSDs).
• To summarize the potential mechanisms of action for GLP in neuroprotection.
• To explore GLP as a novel therapeutic agent for NSDs.

Main Methods:

• Literature review of studies on Ganoderma lucidum polysaccharides (GLP).
• Analysis of research on the structural characterization and biological functions of GLP.
• Examination of studies investigating GLP's effects on nervous system diseases (NSDs).

Main Results:

• Ganoderma lucidum polysaccharides (GLP) exhibit various pharmacological activities, including immune regulation, antioxidant, and anti-inflammatory effects.
• GLP has demonstrated neuroprotective potential in preclinical studies.
• The mechanisms of action involve modulating cellular pathways relevant to neurodegeneration.

Conclusions:

• Ganoderma lucidum polysaccharides (GLP) are a promising candidate for developing new treatments for nervous system diseases (NSDs).
• Further research into GLP's neuroprotective properties and mechanisms is warranted.
• GLP holds potential for improved development and utilization in neurological therapeutics.