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[Allergy caused by Alternaria in children]

A Angrisano1, L Di Berardino, G Montrasio

  • 1Divisione di Pediatria, Presidio ospedaliero di Bollate, Italia.

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|March 1, 1987
PubMed

Insights

Alternaria tenuis molds are significant causes of childhood respiratory diseases like asthma and rhinitis. This study confirms their role as an immunopathogen, highlighting the need for further research.

Area of Science:

  • Mycology
  • Immunology
  • Pediatric Allergy

Context:

  • Molds, particularly Alternaria tenuis, are implicated in respiratory conditions but remain understudied.
  • Previous research has not fully elucidated the role of specific fungi in pediatric allergic diseases.

Purpose:

  • To investigate the role of Alternaria tenuis as an immunopathogen in pediatric rhinitis and asthma.
  • To assess the correlation between skin testing and specific IgE levels (RAST) for Alternaria tenuis.

Summary:

  • A study involving 253 children found that 9.48% had immediate skin reactions to Alternaria tenuis, with 3.55% reacting solely to this fungus.
  • A strong correlation (66%) was observed between positive skin tests and positive Radioallergosorbent Test (RAST) results.
  • The findings suggest Alternaria tenuis plays a significant role in the development of allergic rhinitis and asthma in children.

Impact:

  • Provides evidence supporting Alternaria tenuis as a key allergen in childhood respiratory allergies.
  • Highlights the utility of skin prick tests and RAST in diagnosing Alternaria tenuis-induced allergies.
  • Informs future epidemiological studies and clinical management strategies for pediatric allergic airway diseases.

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