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Designing and making an open source, 3D-printed, punctal plug with drug delivery system.

Twisha Khanna1, John D Akkara2, Vedant Bawa1

  • 1Bachelor of Medicine, Bachelor of Surgery, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

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Researchers developed a 3D-printable punctal plug with an integrated drug delivery system for treating dry eye disease. This cost-effective and personalized approach offers a promising therapeutic option for ocular conditions.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Materials Science

Background:

  • Punctal plugs are crucial for managing dry eye disease (keratoconjunctivitis sicca).
  • Advancements in 3D printing offer potential for personalized medical devices.
  • Integrating drug delivery systems into punctal plugs can improve therapeutic efficacy.

Purpose of the Study:

  • To create an open-source design for a 3D-printable punctal plug.
  • To develop a punctal plug with an integrated drug delivery system.
  • To assess the feasibility and efficiency of 3D printing these plugs.

Main Methods:

  • Utilized FreeCAD for 3D design and ChituBox for slicing.
  • Employed LCD 3D printing (Crealty LD-002R) with biocompatible resin.
  • Focused on creating patient-specific punctal plugs for dry eye management.

Main Results:

  • Successfully 3D printed punctal plugs with a suitable structure.
  • Demonstrated ease of reproduction without complications.
  • Achieved satisfactory results for the designed punctal plugs.

Conclusions:

  • 3D printing provides a cost-effective and rapid method for producing personalized punctal plugs.
  • The developed punctal plugs with drug delivery capabilities show potential for treating ocular diseases.
  • This technology can enhance drug delivery and nasolacrimal pathway management.