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Cytotoxic compounds from marine actinomycetes: Sources, Structures and Bioactivity
Ziyan Qiu1, Yinshuang Wu1, Kunyan Lan1
1Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Acta Materia Medica
|January 2, 2023
Summary
Marine actinomycetes yield numerous natural products with potent cytotoxic and antitumor activities. This review details 254 compounds, focusing on their sources, structures, and anticancer potential.
Area of Science:
- Marine Microbiology
- Natural Product Chemistry
- Pharmacology
Background:
- Marine actinomycetes are prolific sources of bioactive natural products.
- These microorganisms inhabit diverse marine environments, including coral reefs, sponges, and sediments.
- Natural products from marine actinomycetes exhibit significant cytotoxic properties.
Purpose of the Study:
- To review and summarize natural products isolated from marine actinomycetes between 1989 and 2020.
- To highlight the sources, chemical structures, and antitumor activities of these compounds.
- To identify marine actinomycete-derived compounds with potent cytotoxicity.
Main Methods:
- Literature review of scientific publications from 1989 to 2020.
- Compilation and analysis of data on 254 natural products from marine actinomycetes.
- Categorization of compounds based on chemical classes (polyketides, non-ribosomal peptides, etc.).
Main Results:
- A total of 254 natural products were identified from marine actinomycetes.
- Polyketides represent the largest class of these compounds (146).
- Twenty-two compounds demonstrated potent cytotoxicity, with IC50 values in the ng/mL or nM range.
Conclusions:
- Marine actinomycetes are a valuable source of novel cytotoxic and antitumor compounds.
- Further research into these natural products may lead to the development of new cancer therapeutics.
- The review underscores the importance of marine biodiversity for drug discovery.
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