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Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
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Malignancy mimics- diagnostic perplexities for oral and maxillofacial pathologists
Harpreet Kaur1, Deepika Mishra1, Ajoy Roychoudhury2
1Department of Oral Pathology and Microbiology, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
Journal of Oral and Maxillofacial Pathology : JOMFP
|January 2, 2023
Summary
Pathologists can avoid misdiagnosing benign oral lesions as malignant by recognizing common mimics. Correlating clinical, radiological, and advanced pathological findings like immunohistochemistry (IHC) is crucial for accurate diagnosis.
Area of Science:
- Oral Pathology
- Diagnostic Pathology
Background:
- Benign oral lesions can mimic malignancy clinically and histopathologically.
- Diagnostic errors can occur without a systematic approach.
Purpose of the Study:
- To provide a working classification of oral pseudotumors.
- To aid pathologists in differentiating benign lesions from malignancies.
Main Methods:
- Review of clinical case records and pathological specimens (Jan 2018 - Sep 2019).
- Analysis of cases with pseudotumor features, including special stains and immunohistochemistry (IHC).
Main Results:
- Identified common benign oral lesions mimicking malignancy: Immunoglobulin G4-related disease, nodular fasciitis, fibrolipoma, odontogenic keratocyst, juvenile ossifying fibroma, and tumor-induced osteomalacia.
- Highlighted diagnostic dilemmas and the importance of correlating clinicoradiological and microscopic findings.
Conclusions:
- Pathologists must be aware of malignant mimics in oral pathology.
- Correlation of light microscopy with clinical, radiological, and IHC findings is essential for accurate diagnosis.
