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Related Experiment Video

Updated: Aug 15, 2025

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Case report: Pain in anti-DPPX encephalitis.

Tale L Bjerknes¹, Ole Martin Steihaug², Mette Haugen¹

¹Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Frontiers in Neurology

|January 2, 2023

Summary

Dipeptidyl-peptidase-like protein 6 (DPPX) encephalitis is rare but can present with severe pain. Early diagnosis and immunosuppressive treatment lead to favorable outcomes in patients with DPPX-associated autoimmune encephalitis.

Area of Science:

Neuroimmunology
Neurology

Background:

Autoimmune encephalitis targeting potassium channel subunit dipeptidyl-peptidase-like protein 6 (DPPX) is uncommon.
While typically presenting with weight loss, central nervous system hyperexcitability, and cognitive issues, DPPX encephalitis exhibits a heterogeneous clinical spectrum.

Keywords:

anti-dipeptidyl-peptidase-like protein 6 (DPPX)autoimmune encephalitis extremity pain rituximab weight loss

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