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Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

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Integrating mechanical sensor readouts into organ-on-a-chip platforms.

Ingrid Anaya Morales¹, Christina-Marie Boghdady², Benjamin E Campbell²

¹Division of Experimental Medicine, McGill University, Montreal, QC, Canada.

Frontiers in Bioengineering and Biotechnology

|January 2, 2023

Summary

Organs-on-a-chip leverage mechanical cues for realistic tissue modeling, overcoming animal model limitations. This review explores on-chip sensing strategies for measuring these mechanical features, crucial for drug screening and disease research.

Keywords:

biomechanics mechanobiology organ-on-a-chip sensors tissue engineering

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Area of Science:

Biomedical Engineering
Tissue Engineering
Microfluidics

Background:

Organs-on-a-chip (OoC) are advanced tissue-engineered models mimicking human physiology.
Mechanical cues in the culture environment are vital for tissue formation, function, homeostasis, and degeneration.
Current methods for measuring mechanical features on-chip are limited, hindering OoC development.

Purpose of the Study:

To review microfluidically-compatible sensing strategies for OoC.
To explore advances in mechanical analysis techniques for cellular and tissue scales.
To discuss the integration of mechanical sensing in OoC for enhanced applications.

Main Methods:

Review of existing literature on microfluidic sensing and mechanical analysis techniques.
Categorization of sensing strategies based on on-chip advantages.
Discussion of foundational and recent mechanical analysis advancements.

Main Results:

Overview of various microfluidic-compatible sensing strategies for OoC.
Identification of key mechanical analysis techniques applicable to OoC.
Highlighting the importance and integration challenges of mechanical measurements in OoC.

Conclusions:

Mechanical sensing is critical for improving OoC accuracy and predictive power.
Further development of on-chip mechanical measurement techniques is needed.
Integrated mechanical analysis in OoC will advance drug screening, disease modeling, and biological studies.