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Related Experiment Video

Updated: Aug 15, 2025

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

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Light responsive hydrogels for controlled drug delivery.

Yanghui Xing1, Buhui Zeng1, Wang Yang1

  • 1Department of Biomedical Engineering, Shantou University, Shantou, China.

Frontiers in Bioengineering and Biotechnology
|January 2, 2023
PubMed
Summary
This summary is machine-generated.

Light responsive hydrogels offer precise drug delivery by incorporating photosensitive materials. These advanced systems utilize various light triggers for controlled release in diverse therapeutic applications.

Keywords:
drug deliveryhydrogellight responsivephotosensitizerprogrammed release

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Light is a versatile, non-invasive stimulus ideal for controlled external manipulation.
  • Light-responsive hydrogels integrate photosensitive components for targeted drug release.
  • Advances in photosensitizers enhance responsiveness to diverse light sources.

Purpose of the Study:

  • To review the current development of light-responsive hydrogels for controlled drug delivery.
  • To explore the mechanisms, materials, and applications of these advanced hydrogel systems.
  • To discuss challenges and future perspectives in the field.

Main Methods:

  • Incorporation of photosensitive moieties into hydrogel polymeric structures.
  • Utilizing photoisomerization, photochemical reactions, and photothermal reactions for drug release.
  • Development and integration of novel photosensitizers (e.g., rare metal nanostructures, black phosphorus nanoparticles).

Main Results:

  • Successful drug release mechanisms triggered by light stimuli.
  • Enhanced therapeutic effects using UV, near-infrared light, and up-conversion nanoparticles.
  • Broad applicability in delivering drugs, proteins, and genes for various therapies (chemotherapy, immunotherapy, gene therapy, etc.).

Conclusions:

  • Light-responsive hydrogels represent a significant advancement in controlled drug delivery.
  • Optimization strategies focusing on targeting, metabolism, and toxicity are crucial for clinical translation.
  • The field holds substantial promise for improving therapeutic efficacy and patient convenience.