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Related Experiment Video

Updated: Aug 15, 2025

Induction of Complete Transection-Type Spinal Cord Injury in Mice
06:51

Induction of Complete Transection-Type Spinal Cord Injury in Mice

Published on: May 6, 2020

8.6K

A New and Simple Method for Spinal Cord Injury Induction in Mice.

Zahra Zeraatpisheh1,2, Esmaeil Mirzaei3,4, Mohammad Nami1,2

  • 1Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

Basic and Clinical Neuroscience
|January 2, 2023
PubMed
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This summary is machine-generated.

This study introduces a novel, inexpensive instrument for inducing controlled Spinal Cord Injury (SCI) in mice. The new method allows for reproducible SCI studies without complex equipment, aiding research into effective treatments.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Spinal Cord Injury (SCI) results in significant motor and sensory dysfunction with limited treatment options.
  • Animal models are crucial for understanding SCI pathophysiology and developing therapeutic strategies.
  • Existing SCI models often require complex procedures and expensive equipment, limiting their accessibility.

Purpose of the Study:

  • To introduce a novel, simple, cost-effective, and reproducible murine model for inducing Spinal Cord Injury (SCI).
  • To develop an apparatus that minimizes extraneous spinal movement during injury induction.
  • To provide a versatile tool for future SCI research, including drug delivery and tissue engineering.

Main Methods:

  • A novel instrument was designed, comprising a body, an immobilization piece, and a bar-shaped weight.
Keywords:
Animal modelsMiceSpinal cord injury

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  • SCI was induced in male C57BL/6 mice at the T9 level using an 8-g weight for 5, 10, or 15 minutes post-laminectomy.
  • Evaluations included motor function assessment, cavity formation, cell injury, and macrophage infiltration 28 days post-injury.

    • Main Results:

    • The instrument successfully minimized adverse spinal movement without requiring additional stabilizing devices.
    • Motor function was significantly impaired post-injury, with severity correlating to the duration of weight exertion.
    • Histological analysis revealed controllable cavity formation, exacerbated cell injury, and observed macrophage infiltration.

    Conclusions:

    • The novel apparatus reliably induces controllable SCI with clear cavity formation in mice.
    • This method is economical, reproducible, and does not require accessory elements, making it suitable for future SCI studies.
    • The model facilitates research into SCI mechanisms and the evaluation of novel therapeutic interventions.