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Measurement and Analysis of Atomic Hydrogen and Diatomic Molecular AlO, C2, CN, and TiO Spectra Following Laser-induced Optical Breakdown

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Stable sensing platform for diagnosing electrolyte disturbance using laser-induced breakdown spectroscopy.

Weiliang Wang¹, Yuanchao Liu², Yanwu Chu³

¹Wuhan National Laboratory for Optoelectronics (WNLO), Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

Biomedical Optics Express

|January 2, 2023

Summary

This study introduces ordered microarray silicon substrates (OMSS) to improve laser-induced breakdown spectroscopy (LIBS) for rapid electrolyte detection in critical patients. The new method significantly enhances spectral stability and accuracy, aiding clinical diagnosis.

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Area of Science:

Analytical Chemistry
Biomedical Engineering
Spectroscopy

Background:

Electrolyte disturbances are common and dangerous in critical patients, necessitating rapid and accurate detection.
Laser-induced breakdown spectroscopy (LIBS) offers rapid, simultaneous multi-element detection but suffers from serum drying and coffee-ring effects, leading to unstable signals and inaccurate results.

Purpose of the Study:

To develop an improved method for clinical electrolyte detection using LIBS.
To address the limitations of cracking and the coffee-ring effect in LIBS analysis of serum samples.
To create a stable and accurate sensing platform for electrolyte disturbance detection.

Main Methods:

Fabrication of ordered microarray silicon substrates (OMSS) using laser microprocessing.
Optimization of OMSS area for enhanced LIBS detection performance.
Evaluation of the OMSS-LIBS platform using simulated electrolyte disturbance samples (80% human serum).

Main Results:

OMSS significantly reduced the relative standard deviation (RSD) of serum LIBS spectra from over 80.00% to below 15.00%, improving spectral stability.
The optimized OMSS-LIBS platform achieved accurate quantitative detection of Na (RSD < 6.00%, R² = 0.991) and K (RSD < 4.00%, R² = 0.981) within 5 minutes.
Only 10 uL of serum sample is required for detection.

Conclusions:

The developed OMSS-LIBS sensing platform effectively overcomes LIBS limitations for serum electrolyte analysis.
This technology demonstrates high accuracy, stability, and speed for clinical electrolyte detection.
The OMSS-LIBS platform shows significant promise for clinical electrolyte monitoring and other blood-related diagnostics.