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Updated: Aug 15, 2025

The Isolation and Culture of Primary Epicardial Cells Derived from Human Adult and Fetal Heart Specimens
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Mechanotransduction regulates inflammation responses of epicardial adipocytes in cardiovascular diseases

Xiaoliang Liu1, Lei Liu1, Junfei Zhao2

  • 1Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education (MOE), Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Frontiers in Endocrinology
|January 2, 2023
PubMed

Insights

Adipose tissue plays a key role in heart health. Mechanical forces influence cardiac adipocytes, impacting cardiovascular homeostasis and disease development, offering potential therapeutic targets.

Area of Science:

  • Cardiovascular Biology
  • Adipose Tissue Biology
  • Mechanobiology

Background:

  • Adipose tissue regulates cardiovascular homeostasis through bioactive secretions.
  • Adipose tissue disorders are linked to various cardiovascular diseases (CVD).
  • Tissue localization and metabolic state of adipose tissue influence cardiometabolic risk.

Purpose of the Study:

  • To clarify the role of mechanical stress in cardiac adipocyte homeostasis.
  • To explore the interplay between mechanical stress and cardiac function maintenance.
  • To understand adipocyte mechanotransduction in cardiovascular disorders for therapeutic development.

Main Methods:

  • Review of existing literature on adipose tissue, cardiovascular disease, and mechanotransduction.
  • Analysis of the crosstalk between adipose and myocardial tissues in cardiac pathologies.
  • Examination of the impact of mechanical forces on adipocyte development and function.

Main Results:

  • Adipose tissue distribution and metabolic status significantly affect cardiovascular health.
  • Mechanotransduction pathways are critical for adipocyte differentiation, proliferation, and homeostasis.
  • Abnormal cardiac adipose tissue distribution can directly or indirectly impair cardiac function.

Conclusions:

  • Mechanical stress is a vital factor in cardiac adipocyte biology.
  • Understanding adipocyte mechanotransduction offers novel therapeutic avenues for cardiovascular diseases.
  • Targeting mechanical signaling in cardiac adipocytes may improve cardiovascular homeostasis.

Keywords:
adipocytecardiomyocytescardiovascular diseasescrosstalkmechanotransduction

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