BIMMS: A versatile and portable system for biological tissue and electrode-tissue interface electrical...

Area of Science:

• Biomedical Engineering
• Neuroscience
• Electrical Engineering

Background:

• Accurate electrical characterization of biological tissues and electrode-tissue interfaces is crucial for developing advanced neural interfaces and diagnostic tools.
• Existing solutions can be expensive and lack flexibility, hindering widespread research and development.

Purpose of the Study:

• To present a low-cost, compact, and open-source USB-controlled platform for electrical measurements.
• To enable potentiostatic and galvanostatic electrical impedance spectroscopy (EIS) and cyclic voltammetry (CV) with tissue-safe parameters.

Main Methods:

• Utilized an Analog Discovery 2 platform for data acquisition and generation.
• Implemented potentiostatic/galvanostatic EIS up to 10 MHz and CV with +-8 V compliance and 2.4 mA current.
• Performed accuracy analysis and comparison with a commercial impedance analyzer.

Main Results:

• The platform demonstrated accurate impedance measurements.
• Successful application in measuring impedance on implanted electrodes for neural stimulation.
• Validated performance on an ex-vivo calf brain sample.

Conclusions:

• The developed platform provides a cost-effective and versatile solution for bioelectrical measurements.
• It is suitable for research involving neural stimulation and tissue interface characterization.
• The open-source nature promotes accessibility and further development in the field.