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Mice genetically selected for differences in open-field activity after ethanol.

J C Crabbe1, E R Young, C M Deutsch

  • 1Department of Medical Psychology, Oregon Health Sciences University, Portland.

Pharmacology, Biochemistry, and Behavior
|July 1, 1987
PubMed
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Selective breeding created mice lines with differing ethanol sensitivity. These new lines help study ethanol

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Ethanol's effects on behavior are complex and influenced by genetics.
  • Understanding genetic contributions to ethanol sensitivity is crucial for addiction research.

Purpose of the Study:

  • To develop distinct mouse lines with varying responses to ethanol-induced activity.
  • To create a genetic resource for studying the neurobiology of ethanol's effects.

Main Methods:

  • Selective breeding of genetically heterogeneous mice based on ethanol-induced open-field activity.
  • Two generations of selection for increased (FAST) and decreased (SLOW) activity responses.
  • Behavioral testing in an open field following saline and ethanol (1.5 g/kg) injections.

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Main Results:

  • Significant divergence between FAST and SLOW lines after four generations of selective breeding.
  • Established distinct genetic lines exhibiting differential sensitivity to ethanol's behavioral effects.

Conclusions:

  • The developed mouse lines provide a valuable tool for investigating the neuropharmacological underpinnings of ethanol's activating and rewarding properties.
  • These lines facilitate research into the genetic basis of ethanol sensitivity and behavior.