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Application of engineered extracellular vesicles to overcome drug resistance in cancer

Taichiro Nonaka1,2

  • 1Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, United States.

Frontiers in Oncology
|January 2, 2023
PubMed

Insights

Extracellular vesicles (EVs) offer a promising new method for targeted cancer therapy. These engineered vesicles can deliver therapeutic agents directly to tumor cells, overcoming limitations of current molecular targeted agents.

Area of Science:

  • Oncology
  • Nanotechnology
  • Molecular Biology

Background:

  • Molecular targeted agents have improved cancer patient survival and quality of life.
  • Limitations include toxicities in normal tissues and premature immune responses.
  • These issues hinder the full efficacy of current targeted cancer therapies.

Purpose of the Study:

  • To review the progress in understanding extracellular vesicle (EV) biology.
  • To discuss the chemical and genetic modification of EVs for therapeutic applications.
  • To highlight EVs as a promising platform for next-generation cancer payloads.

Main Methods:

  • Review of current scientific literature on EV biology and engineering.
  • Analysis of chemical and genetic modification strategies for EVs.
  • Discussion of clinical and preclinical studies utilizing engineered EVs.

Main Results:

  • Extracellular vesicles (EVs) can be engineered to carry therapeutic payloads.
  • EVs demonstrate potential for targeted delivery to tumor cells.
  • EVs can overcome limitations associated with current targeted therapies.

Conclusions:

  • Engineered extracellular vesicles represent a promising approach for advanced cancer therapy.
  • Further research into EV modification and application is warranted for clinical translation.
  • EV-based therapies may offer improved efficacy and reduced toxicity in cancer treatment.
Keywords:
cancerdrug deliveryengineered EVexosomeextracellular vesicle

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