How Do Cannabis and Synthetic Cannabinoids Affect Neurocognitive Functions?

In this study, the losses of neurocognitive function caused by the use of cannabis and synthetic cannabinoid were studied on specific cognitive areas (attention and working memory, executive functions, visuospatial perception, learning and memory, planning and problem solving, word naming) and were described in comparision with healthy controls (control group).

In this study, while 52 participants who applied to Ege University Faculty of Medicine Department of Mental Health and Mental Disorders Drug Addiction Treatment Center Clinic between March 2015 - February 2017 and used cannabis at least for one year in the past and 51 participants who used synthetic cannabinoids for at least one year in the past were participant groups with a history of substance use; 57 staff/student of Ege University with no history of any substance use were participants of the control group. The research sample consisted of 160 participants. The sample group consisted of 160 men aged 18-35, and also 16 participants aged 36-54 were involved in the study in order to observe neuropsychological functions that changed with age. Stroop Test for attention area, Raven Standart Progressive Matrices Test for executive functions area, Line Orientation Test and Cancellation Test for visuospatial perception area, Serial Digit Learning Test and Öktem Verbal Memory Progresses Scale for learning and memory area, The Tower of London Test for planning and problem solving skill, Boston Naming Test for word naming area were used.

In this study, while the lowest perfomance on the ability of focused attention, visuospatial cognition, visual scanning, orientation, sustained attention, general ability, short-term memory, learning, long-term memory, word naming was shown by the participants with a history of synthetic cannabis use, the participants with a history of cannabis use had the lowest performance on the ability of response rate, perseveration, conceptualizing, abstract thinking, changing sets, recognition. Participants' history of substance use did not affect the ability of planning and problem solving.

In conclusion, this study suggests that the addition of cognitive rehabilitation programs to medical and psychosocial improvement studies carried out in the field of addiction will increase the success.