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Updated: Aug 15, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Dynamic DNA Nanostructures for Cell Manipulation.

Lu Yu¹, Zongrui Ma², Qunye He³

¹Department of Endocrinology and Metabolism, The First People's Hospital of Changde City, Renmin Middle Road 818, Changde, Hunan 415000, P. R. China.

ACS Biomaterials Science & Engineering

|January 2, 2023

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Dynamic DNA nanostructures offer precise cell manipulation by reconfiguring on cell membranes. This review explores their mechanisms, anchoring, and applications like targeted drug delivery and cell assembly.

Area of Science:

Biotechnology
Nanotechnology
Cell Biology

Background:

Dynamic DNA nanostructures possess reconfigurable elements, enabling structural changes in response to stimuli.
Anchoring these nanostructures onto cell membranes presents a promising strategy for controlled cell manipulation.

Purpose of the Study:

To review recent advancements in dynamic DNA nanostructures for cell manipulation.
To introduce common mechanisms, anchoring strategies, and applications of these nanostructures on cell membranes.

Main Methods:

Review of literature on dynamic DNA nanostructures and their applications in cell manipulation.
Categorization of mechanisms and anchoring strategies.
Summarization of potential applications and future challenges.

Keywords:

DNA nanostructure cell manipulation dynamic assembly

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Last Updated: Aug 15, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

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Published on: September 27, 2019

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Main Results:

Dynamic DNA nanostructures can be effectively anchored to cell membranes using various strategies.
Applications include programming cell membrane receptors, modulating ligand activity, targeted drug delivery, and cell assembly into clusters.
Several mechanisms driving the dynamic reconfiguration of DNA nanostructures are discussed.

Conclusions:

Dynamic DNA nanostructures are versatile tools for advanced cell manipulation.
Further research is needed to address challenges and fully realize their potential in biomedical applications.