Computational Models of Typical and Atypical Brain Network Development

Over the last decade, the organization of brain networks at both micro- and macroscales has become a key focus of neuroscientific inquiry. This has revealed fundamental features of brain network organization-small-worldness, modularity, heavy-tailed degree distributions-and has highlighted how these structural features support brain function. However, the driving forces that shape brain networks over the course of development have begun to be explored only recently. Here, we review recent efforts to gain insights into the mechanisms of brain development through generative modeling of both macroscale human brain networks and microscale cellular connectomes in Caenorhabditis elegans and other organisms. We show how these mathematical models can begin to shed light on the biological processes that drive and constrain the development of brain networks. Finally, we show how generative network models can translate genetic and environmental differences into variability in developmental trajectories, leading to diverse cognitive and mental health outcomes in children and young people.