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Invasive Papillary Adenocarcinoma of Gallbladder: A Case Report
S N Karim1, B K Basu, M N Nowsher
1Dr Syeda Noorjahan Karim, Assistant Professor, Department of Pathology, Gazi Medical College, Khulna, Bangladesh;
Mymensingh Medical Journal : MMJ
|January 3, 2023
Summary
Papillary gallbladder adenocarcinoma (PGA) is a rare cancer. Early detection is crucial for this silent malignancy, as a delayed diagnosis often leads to fatal outcomes.
Area of Science:
- Gastroenterology
- Surgical Oncology
Background:
- Papillary gallbladder adenocarcinoma (PGA) accounts for 5.0% of gallbladder malignancies.
- Early diagnosis of PGA is critical due to its silent progression and often fatal late diagnosis.
Observation:
- A 63-year-old female presented with right upper quadrant pain and a palpable gallbladder.
- Ultrasound revealed a hypoechoic shadow suggestive of gallstones, but intraoperative findings showed a papillary growth.
- Radical cholecystectomy with lymph node dissection and hepatic resection was performed.
Findings:
- Histopathology confirmed a well-differentiated invasive papillary adenocarcinoma with muscle invasion.
- No liver metastasis was detected.
- Lymph nodes exhibited reactive hyperplasia.
Implications:
- This case highlights the importance of thorough intraoperative examination during cholecystectomy, even when initial imaging suggests benign conditions.
- Aggressive surgical management, including radical resection, is vital for potentially curative treatment of PGA.
- Further research into early diagnostic markers for PGA is warranted to improve patient outcomes.
